Observational determination of dose-response curves
in hallucinogen-treated monkeys
by
Brewster JM, Siegel RK, Johnson CA, Jarvik ME
Int Pharmacopsychiatry. 1976;11(2):102-8

ABSTRACT

An objective behavioral profile that was previously shown to distinguish the effects of hallucinogens from those of other classes of drugs was used here to further study hallucinogenic behaviors. Saline, d-amphetamine sulfate and five doses of dimethyltryptamine (DMT) were administered to solitary adolescent rhesus monkeys in a totally dark environment and their behavior was observed via infrared monitors, videotaped, and scored in a number of categories. Scores in the following categories systematically increased with ascending doses of DMT; exploration, locomotion, stereotypy, spasm, tracking and duration of inappropriate behavior. In addition, some behaviors sensitive to hallucinogens occurred with greater frequency in the dark than in a previous study conducted in the light. Behaviors such as tracking and fear grimaces, usually associated with specific stimuli, emerged in the absence of such stimuli in the dark. These results suggested hallucinogen-induced changes in perceptual-motor systems, if not hallucinations per se.

Peyote
Cannabis
Fly agaric
Psilocybe
Mescaline
Kava kava
Ayahuasca
Hallucinogens
St John's wort
Salvia Divinorum
Fluoxetine and LSD
Psychoactive fungi
Hallucinogens and redemption
Hofmann's LSD: My Problem Child
Hallucinogen-treated blind monkeys
Monkeys don't enjoy hallucinogens very much
Naturally-growing hallucinogens and dissociative agents

HOME
HedWeb
Primates.com
Future Opioids
BLTC Research
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?